Effect of laparotomy and laparoscopy on the establishment of lung metastasis in a murine model.

@article{Shiromizu2000EffectOL,
  title={Effect of laparotomy and laparoscopy on the establishment of lung metastasis in a murine model.},
  author={Akio Shiromizu and Toshihiro Suematsu and Koji Yamaguchi and Norio Shiraishi and Yosuke Adachi and Seigo Kitano},
  journal={Surgery},
  year={2000},
  volume={128 5},
  pages={799-805}
}
BACKGROUND Laparoscopic surgery is now applied to patients with gastrointestinal cancer. In animal studies, extraperitoneal tumor growth has been significantly less after laparoscopy than after laparotomy, but whether hematogenous metastasis occurs less frequently after laparoscopy is unknown. The aim of this study was to compare the frequency and growth of lung metastasis and serum levels of IL-6 and tumor necrosis factor-alpha (TNF-alpha) in mice treated by laparotomy and in mice treated by… CONTINUE READING

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