Effect of laminectomy and anesthesia upon spinal cord blood flow.

@article{Hitchon1984EffectOL,
  title={Effect of laminectomy and anesthesia upon spinal cord blood flow.},
  author={Patrick W. Hitchon and Jeffrey M. Lobosky and T. Yamada and James C. Torner},
  journal={Journal of neurosurgery},
  year={1984},
  volume={61 3},
  pages={
          545-9
        }
}
Spinal cord blood flow (SCBF) in 10 sheep subjected to laminectomy at L6-7, T6-7, and C7-T1 was compared to that of 10 control sheep subjected to anesthesia alone. Blood flow was measured using the radioactive microsphere technique, with the PaCO2 maintained at 40 +/- 2 mm Hg. Both laminectomy and control animals showed a decrease in SCBF at a rate of 7% to 16%/hr for the 3 hours following the first blood flow determination. When prelaminectomy and postlaminectomy SCBF values were compared to… 
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12 Citations

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References

SHOWING 1-10 OF 25 REFERENCES
Effects of laminectomy on spinal cord blood flow.
TLDR
The data indicate that laminectomy can cause a significant decline in spinal cord blood flow, and the mechanism(s) for this laminationectomy-induced depression of SCBF are unknown, although a temperature-induced vasoconstriction is suspected.
Effects of anesthesia and laminectomy on regional spinal cord blood flow in conscious sheep.
TLDR
Blood flow for the whole spinal cord, central cord, and peripheral cord has been measured at all segmental levels using radioactive microspheres in conscious sheep and the effect of laminectomy could adversely influence results obtained from studies using invasive techniques to measure SCBF.
The Response of Spinal Cord Blood Flow to High‐Dose Barbiturates
TLDR
Findings of a significant reduction in SCBF in response to high-dose barbiturate therapy are suggestive of a protective effect of barbiturates upon spinal cord injury as occurs in the brain.
Spinal cord blood flow in dogs 1
TLDR
The response of the cord vessels to the blood gases was very similar to that of the brain and the vasoconstrictor effect of hypocarbia was absent or decreased in hypoxia.
Spinal cord blood flow in dogs. 2. The effect of the blood gases.
  • I. Griffiths
  • Biology, Medicine
    Journal of neurology, neurosurgery, and psychiatry
  • 1973
TLDR
The response of the cord vessels to the blood gases was very similar to that of the brain and the vasoconstrictor effect of hypocarbia was absent or decreased in hypoxia.
Spinal evoked potential in the cat: effects of asphyxia, strychnine, cord section and compression.
Spinal cord energy metabolism in normal and postlaminectomy cats.
TLDR
The results indicate that although laminectomy can reduce SCBF, the degree of this reduction is insufficient to adversely affect spinal cord energy metabolism, and tissue from beneath or near the laminationectomy site is viable and essentially normal.
Spinal cord blood flow as affected by changes in systemic arterial blood pressure.
The authors used the hydrogen clearance method to measure focal spinal cord blood flow (SCBF) in the rhesus monkey over a wide range of mean arterial blood pressures (MAP) in an attempt to test the…
Spinal cord blood flow in dogs: the effect of blood pressure
  • I. Griffiths
  • Biology, Medicine
    Journal of neurology, neurosurgery, and psychiatry
  • 1973
TLDR
A study has been made into the effects of blood pressure on the spinal cord blood flow and the results are discussed in relation to the cerebral circulation and to some aspects of experimental cord disease.
Spinal evoked response: peripheral nerve stimulation in man.
  • R. Cracco
  • Biology
    Electroencephalography and clinical neurophysiology
  • 1973
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