Effect of l-glutamate, injected into the posterior hypothalamus, on blood pressure and heart rate in unanesthetized and unrestrained rats

@article{Ohta1985EffectOL,
  title={Effect of l-glutamate, injected into the posterior hypothalamus, on blood pressure and heart rate in unanesthetized and unrestrained rats},
  author={Hisashi Ohta and S. Nakamura and S. Watanabe and Showa Ueki},
  journal={Neuropharmacology},
  year={1985},
  volume={24},
  pages={445-451}
}
In vivo release patterns and cardiovascular properties of inhibitory and excitatory amino acids in the hypothalamus
TLDR
It is concluded that the inhibitory amino acids taurine and GABA released from hypothalamic neurons possess a tonic hypotensive function and the excitatory amino acid glutamate seems to possess a hypertensive function in counteracting a fall of blood pressure.
Decrease in glutamic acid decarboxylase level in the hypothalamus of spontaneously hypertensive rats
TLDR
It is demonstrated that the spontaneously hypertensive rat has fewer neurons synthesizing GABA and less GAD67 mRNA in the caudal hypothalamus than do Wistar–Kyoto rats.
The Hypothalamus and Cardiovascular Regulation
TLDR
This chapter surveys the literature describing the different neuronal phenotypes in the hypothalamus and their projections to cardiovascular neurones elsewhere in the brain and spinal cord.
Descending projections of the posterior nucleus of the hypothalamus: Phaseolus vulgaris leucoagglutinin analysis in the rat
TLDR
The present report describes the descending projections of the PH in the rat by using the anterograde anatomical tracer, Phaseolus vulgaris leucoagglutinin, to examine the descending projection of the posterior nucleus of the hypothalamus.
...
...

References

SHOWING 1-10 OF 14 REFERENCES
Central Nervous System Mechanisms Involving GABA Influence Arterial Pressure and Heart Rate in the Cat
TLDR
Results indicate that activation of GABA receptors in the region of the hindbrain causes hypotension and bradycardia, and that both of these responses are mediated by a reduction in sympathetic outflow to the vasculature and heart.
Review of the Role of the Central Serotonergic Neuronal System in Blood Pressure Regulation
TLDR
The reduction in sympathetic outflow produced by increasing brain serotonin levels in dogs protects the heart against ventricular fibrillation and may, therefore, constitute a reasonable adjunct in the management of high-risk, cardiac-arrest patients.
Absence of sympathetic cholinergic vasodilatation in cats during early stages of affective behaviour elicited by stimulation of central amygdala, postero-lateral hypothalamus and locus coeruleus.
TLDR
The cardiovascular pattern including sustained vasoconstriction of the vessels of the hindlimbs was supposed to be of greater importance for the induction of hypertension than the cardiovascular pattern, including sympathetic cholinergic vasodilatation.
Cardiovascular control by cholinergic mechanisms in the central nervous system.
TLDR
The function of catecholaminergic pathways in the central connections of the autonomic nervous system and the development of drugs which lower blood pressure through stimulation of central adrenergic sites have fostered precocious ad­ vances involving the biogenic amines.
...
...