Effect of kolanut on the pharmacokinetics of the antimalarial drug halofantrine

  title={Effect of kolanut on the pharmacokinetics of the antimalarial drug halofantrine},
  author={Yetunde T. Kolade and Chinedum P Babalola and Ajibola Akinyemi Olaniyi and Gerhard K E Scriba},
  journal={European Journal of Clinical Pharmacology},
To study the effect of the concomitant consumption of kolanut, a caffeine-containing nut, on the pharmacokinetics of halofantrine. A single dose of 500 mg halofantrine hydrochloride was orally administered either alone or concomitant with 12.5 g kolanut to 15 healthy male volunteers in a Latin-square randomized crossover design with a wash-out period of 6 weeks between treatments. Blood samples were collected and analyzed by HPLC for halofantrine and the active metabolite N-desbutylhalofantrine… CONTINUE READING

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Pharmacokinetic and pharmacodynamic interaction

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