Effect of ketoconazole on isolated mitochondria from Candida albicans.

  title={Effect of ketoconazole on isolated mitochondria from Candida albicans.},
  author={Makoto Shigematsu and Jun Uno and Tadashi Arai},
  journal={Antimicrobial agents and chemotherapy},
  volume={21 6},
Ketoconazole, an oral antimycotic imidazole drug, blocked the transport of electrons in the respiratory chain of Candida albicans under aerobic conditions with different substrates, such as NADH and succinate. This effect was a nonspecific inhibition of NADH oxidases and succinate oxidases. The addition of ketoconazole to C. albicans mitochondria without a substrate resulted in strong reduction of cytochrome a3, as revealed by difference spectra (reduced versus oxidized). This indicated that… CONTINUE READING

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