Effect of kava extract and individual kavapyrones on neurotransmitter levels in the nucleus accumbens of rats

@article{Baum1998EffectOK,
  title={Effect of kava extract and individual kavapyrones on neurotransmitter levels in the nucleus accumbens of rats},
  author={Siedy S{\"a}llstr{\"o}m Baum and Regina Luise Hill and Hans Rommelspacher},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={1998},
  volume={22},
  pages={1105-1120}
}
Extracts of kava (Piper methysticum) induce acute anxiolytic-like behavioral changes in mice
TLDR
This study systematically characterized the acute dosage-dependent anxiolytic and sedative effects of kava extract in well established quantitative murine behavioral assays and compared kava- and diazepam-induced behavioral changes.
Therapeutic Potential of Kava in the Treatment of Anxiety Disorders
TLDR
Clinical studies have shown that kava and kavalactones are effective in the treatment of anxiety at subclinical and clinical levels, anxiety associated with menopause and anxiety due to various medical conditions, and kava should be used with caution.
Kava: A Comprehensive Review of Efficacy, Safety, and Psychopharmacology
TLDR
The current weight of evidence supports the use of kava in treatment of anxiety with a significant result occurring in four out of six studies reviewed, and more studies are required to assess comparative efficacy and safety versus established pharmaceutical comparators.
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It is concluded from the findings that limbic structures and, in particular, the amygdalar complex represent the preferential site of action for both D,L-kavain and the kava extract and the participation of these structures in modulating emotional processes may explain the promotion of sleep, even in the absence of sedation.
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TLDR
Both extracts showed analgesic effects in both tests, and the antinociceptive properties of the aqueous extract of the intoxicating beverage kava and the lipid soluble extract (kava resin) were tested by the tail immersion and abdominal constriction methods.
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TLDR
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