Effect of kappa-opioid receptor agonists U69593, U50488H, spiradoline and salvinorin A on cocaine-induced drug-seeking in rats

@article{Morani2009EffectOK,
  title={Effect of kappa-opioid receptor agonists U69593, U50488H, spiradoline and salvinorin A on cocaine-induced drug-seeking in rats},
  author={Aashish S. Morani and Bronwyn M Kivell and Thomas E. Prisinzano and Susan Schenk},
  journal={Pharmacology Biochemistry and Behavior},
  year={2009},
  volume={94},
  pages={244-249}
}
Our previous work indicated that pretreatment with the selective kappa-opioid receptor (KOPr) agonist, U69593, attenuated the ability of priming injections of cocaine to reinstate extinguished cocaine-seeking behavior. The present study expanded these initial tests to include other traditional KOPr agonists, U50488H, spiradoline (SPR), and salvinorin A (Sal A), an active constituent of the plant Salvia divinorum. Following acquisition and stabilization of cocaine self-administration, cocaine… CONTINUE READING

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