Effect of kaempferol on the production and gene expression of monocyte chemoattractant protein-1 in J774.2 macrophages.

@article{Kowalski2005EffectOK,
  title={Effect of kaempferol on the production and gene expression of monocyte chemoattractant protein-1 in J774.2 macrophages.},
  author={Jan Kowalski and Arkadiusz Samojedny and Monika Paul and Grazyna Pietsz and Tadeusz Wilczok},
  journal={Pharmacological reports : PR},
  year={2005},
  volume={57 1},
  pages={107-12}
}
Monocyte chemoattractant protein-1 (MCP-1) is produced by activated macrophages, and is involved in pathogenesis of cardiovascular and neurodegenerative disorders. There is a need to develop drugs that inhibit excessive infiltration of monocytes and lymphocytes to the arterial wall and central nervous system. The aim of this study was to evaluate the effect of kaempferol on the (MCP-1) gene expression and MCP-1 protein release by J774.2 macrophage cultures in vitro. Kaempferol given both before… CONTINUE READING