Effect of itraconazole on the pharmacokinetics and pharmacodynamics of zolpidem

Abstract

Objective: Zolpidem is a short-acting␣imidazopyridine hypnotic which is biotransformed in humans mainly by CYP3A4. Itraconazole strongly interacts with many substrates of CYP3A4 such as midazolam and triazolam. In this study, the effect of itraconazole on the pharmacokinetics and pharmacodynamics of zolpidem was investigated to uncover a possible clinically… (More)
DOI: 10.1007/s002280050439

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