Effect of itopride on gastric emptying in longstanding diabetes mellitus

@article{Stevens2008EffectOI,
  title={Effect of itopride on gastric emptying in longstanding diabetes mellitus},
  author={Julie E. Stevens and Antonia Russo and Anne F. Maddox and Christopher K. Rayner and Liza K. Phillips and Nicholas J. Talley and Monique Gigu{\`e}re and Michael Horowitz and K. L. Jones},
  journal={Neurogastroenterology \& Motility},
  year={2008},
  volume={20}
}
Abstract  Delayed gastric emptying (GE) occurs in 30–50% of patients with longstanding type 1 or 2 diabetes, and represents a major cause of morbidity. Current therapeutic options are limited. We aimed at evaluating the effects of itopride on GE in patients with longstanding diabetes. Twenty‐five patients (20 type 1, 5 type 2; 10 males, 15 females; mean age 45.2 ± 2.7 years; body mass index 27.5 ± 0.9 kg m−2; duration of diabetes 20.2 ± 2.4 years) were enrolled in a double‐blind, placebo… 

Longitudinal evaluation of gastric emptying in type 2 diabetes.

Effects of rehabilitation management on gastric emptying function in older adults with diabetes.

TLDR
It was shown that appropriate rehabilitation exercise combined with prokinetic agent may improve gastric emptying in some geriatric type 2 diabetic patients and help control their blood glucose.

Prokinetics in Diabetic Gastroparesis

TLDR
The present knowledge of prokinetics is summarized, with emphasis on medications currently available, as well as drugs under clinical investigation, including some agents in advanced clinical trials that are likely to be used in the treatment of diabetic gastroparesis in the future.

Diabetic Gastroparesis

TLDR
The management of diabetic gastroparesis is less than optimal, partly because the pathogenesis has not been clearly defined, and treatment approaches include dietary modification and optimization of glycaemia, and the use of prokinetic drugs.

Effects of Promotility Agents on Gastric Emptying and Symptoms: A Systematic Review and Meta-analysis.

TLDR
In a meta-analysis of published trials, promotility agents were found to significantly accelerate GE (when optimal test methods were used) and to produce significant improvements in UGI symptoms.

A Prospective Multicentric Postmarketing Observational Study to Characterize the Patient Population with Reduced Gastrointestinal Motility among Indian Diabetic Patients Receiving Itopride: The Progress Study

TLDR
Light is shed on the role of prokinetics, not only for symptom relief but also for improving glycemic control in diabetic patients with reduced GI motility, thus providing a holistic approach for the management of these patients.

A PROKINETIC AGENT WITH A DUAL EFFECT - ITOPRIDE - IN THE TREATMENT OF DYSMOTILITY

TLDR
Itopride is a safe prokinetic agent with positive influence on the symptoms of functional dyspepsia such as postprandial fullness, bloating, and gastric emptying and could also be used for the therapy of the mild form of gastro-oesophageal reflux.

A multicenter randomized trial comparing rabeprazole and itopride in patients with functional dyspepsia in Japan: the NAGOYA study

TLDR
Acid-suppressive therapy with RPZ is useful for PDS as well EPS in Japanese FD patients (UMIN Clinical Trials Registry number: UMIN 000013962), and RPZ showed a significant decrease in the Rate of Change in FD score within 1 week, which was maintained until after 4 weeks.

Management of Gastroparesis: Beyond Basics

Opinion statementGastroparesis is defined as the presence of delayed gastric emptying in the absence of mechanical obstruction, with a variety of upper gastrointestinal symptoms. Although measurement

Pathophysiology and management of gastroparesis

TLDR
Gastroparesis is characterized by upper gastrointestinal symptoms associated with delayed gastric emptying, without mechanical obstruction, and probably represents a major cause of poor glycemic control in diabetics.

References

SHOWING 1-10 OF 43 REFERENCES

Relationship between the Effects of Cisapride on Gastric Emptying and Plasma Glucose Concentrations in Diabetic Gastroparesis

TLDR
The effect of cisapride on gastric emptying, at least that of liquids, in patients with diabetic gastroparesis appears to be dependent on the plasma glucose concentration.

Acute and chronic effects of domperidone on gastric emptying in diabetic autonomic neuropathy

TLDR
Gastric emptying was studied with a double radioisotopic method in 12 patients with insulin-dependent diabetes mellitus complicated by autonomic neuropathy and in 22 control subjects, and symptoms of gastroparesis were less after domperidone.

Insulin-induced hypoglycemia accelerates gastric emptying of solids and liquids in long-standing type 1 diabetes.

TLDR
Insulin-induced hypoglycemia accelerates gastric emptying of solids and liquids in long-standing type 1 diabetes, even in those patients with delayed emptying, and is likely to be an important mechanism in the counter-regulation of hyp glucosecemia.

Hyperglycemia attenuates the gastrokinetic effect of erythromycin and affects the perception of postprandial hunger in normal subjects.

TLDR
Gastric emptying of a solid meal is slower, when compared with euglycemia, even after administration of erythromycin, and the perception of postprandial hunger is reduced at a blood glucose concentration of approximately 15 mmol/l.

Prevalence of delayed gastric emptying in diabetic patients and relationship to dyspeptic symptoms: a prospective study in unselected diabetic patients.

TLDR
This prospective study shows that delayed gastric emptying can be observed in 28% of unselected patients with diabetes and upper gastrointestinal sensations scored during the gastrics emptying tests do predict the rate of gastric emptied to some extent and sensation experienced during daily life does not.

Improvement of gastric emptying in diabetic gastroparesis by erythromycin. Preliminary studies.

TLDR
Preliminary results suggest that erythromycin may have therapeutic value in patients with severe diabetic gastroparesis, and shortened the prolonged gastric-emptying times for both liquids and solids to normal.

The effect of erythromycin on gastric emptying is modified by physiological changes in the blood glucose concentration

TLDR
After administration of erythromycin, gastric emptying and intragastric distribution of solids and liquids is influenced by physiological changes in the blood glucose concentration.

A double‐blind, randomized, placebo‐controlled trial of itopride (100 and 200 mg three times daily) on gastric motor and sensory function in healthy volunteers

TLDR
In healthy subjects, itopride reduced total PP gastric volume without accelerating gastric emptying or significantly altering gastric motor and sensory function in healthy individuals.