Effect of ispronicline, a neuronal nicotinic acetylcholine receptor partial agonist, in subjects with age associated memory impairment (AAMI).

@article{Dunbar2007EffectOI,
  title={Effect of ispronicline, a neuronal nicotinic acetylcholine receptor partial agonist, in subjects with age associated memory impairment (AAMI).},
  author={Geoffrey C. Dunbar and Fraser Inglis and Ramana V Kuchibhatla and Tonmoy Sharma and Mark Tomlinson and James K. Wamsley},
  journal={Journal of psychopharmacology},
  year={2007},
  volume={21 2},
  pages={171-8}
}
Cognitive decline seen in the normal elderly is associated with selective loss of neuronal nicotinic acetylcholine receptors (nAChRs). Nicotine given either by inhalation or transdermally helps cognition, but unacceptable side effects limit its utility. The present study assessed the safety, tolerability and effect on cognition of ispronicline, a highly selective partial agonist at the 4beta2 nAChR, in elderly subjects (n =76) with age associated memory impairment (AAMI). This double-blind… CONTINUE READING