Effect of ischemia on mechanical function and high-energy phosphates in rabbit myocardium.

@article{Nishioka1982EffectOI,
  title={Effect of ischemia on mechanical function and high-energy phosphates in rabbit myocardium.},
  author={Kenya Nishioka and Jay M Jarmakani},
  journal={The American journal of physiology},
  year={1982},
  volume={242 6},
  pages={H1077-83}
}
This study was designed to evaluate the effect of ischemia and reperfusion on myocardial mechanical function and high-energy phosphates in the neonate. All studies were performed utilizing the isolated arterially perfused septal preparation of newborn and adult rabbit hearts that were maintained at 27, 33, or 37 degrees C and paced at 90 beats/min. After mechanical function had been stabilized, 60 min of global ischemia was induced and was followed by 60 min of reperfusion. The muscle was kept… CONTINUE READING

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