Effect of irradiation on cytokine production, MHC antigen expression, and vaccine potential of interleukin-2 and interferon-gamma gene-modified melanoma cells.

@article{Abdelwahab1996EffectOI,
  title={Effect of irradiation on cytokine production, MHC antigen expression, and vaccine potential of interleukin-2 and interferon-gamma gene-modified melanoma cells.},
  author={Z A Abdel-wahab and Mohammed M. Dar and David Barry Hester and Carol E. Vervaert and Ramarao Gangavalli and Jack R. Barber and Timothy L. Darrow and Hillard F. Seigler},
  journal={Cellular immunology},
  year={1996},
  volume={171 2},
  pages={
          246-54
        }
}
Recent studies have shown that tumor cells transduced with interleukin-2 (IL-2) or interferon-gamma (IFN-gamma) genes stimulated a potent and specific antitumor immunity in experimental animals. For use as a human vaccine, tumor cells must be inactivated by irradiation to ensure the arrest of their growth. This study was undertaken to examine the effects of irradiation (10,000 rad) on the growth characteristics and vaccine potential of IL-2 and IFN-gamma-modified human melanomas and B16 murine… CONTINUE READING
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