Effect of iron and ascorbate on uroporphyria in ascorbate-requiring mice as a model for porphyria cutanea tarda.

@article{Gorman2007EffectOI,
  title={Effect of iron and ascorbate on uroporphyria in ascorbate-requiring mice as a model for porphyria cutanea tarda.},
  author={Nadia Gorman and Adrian Zaharia and Heidi S Trask and Juliana G. Szakacs and Nicholas J. Jacobs and Judith M. Jacobs and Dominic J. Balestra and Jacqueline F. Sinclair and Peter R. Sinclair},
  journal={Hepatology},
  year={2007},
  volume={45 1},
  pages={187-94}
}
UNLABELLED Excess hepatic iron is known to enhance both porphyria cutanea tarda (PCT) and experimental uroporphyria. Since previous studies have suggested a role for ascorbate (AA) in suppressing uroporphyria in AA-requiring rats (in the absence of excess iron), the present study investigated whether AA could suppress uroporphyria produced by excess hepatic iron. Hepatic URO accumulation was produced in AA-requiring Gulo(-/-) mice by treatment with 3,3',4,4',5-pentachlorbiphenyl, an inducer of… CONTINUE READING