Effect of ipratropium bromide treatment on oxygen saturation and sleep quality in COPD.

@article{Martin1999EffectOI,
  title={Effect of ipratropium bromide treatment on oxygen saturation and sleep quality in COPD.},
  author={R. J. Martin and B L Bartelson and P E Smith and David W Hudgel and Deborah Lewis and G Pohl and Paul Koker and Joseph F. Souhrada},
  journal={Chest},
  year={1999},
  volume={115 5},
  pages={
          1338-45
        }
}
STUDY OBJECTIVES Patients with COPD are at risk of experiencing a deterioration in arterial oxygen saturation (SaO2) during sleep, which is generally most pronounced during rapid eye movement (REM) sleep. Increased cholinergic tone has been suggested as a contributing factor to this decrease in SaO2. Therefore, we investigated whether 4-week treatment with ipratropium bromide inhalation solution 0.02% (qid) could improve sleep characteristics in COPD. DESIGN Randomized, placebo-controlled… 
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TLDR
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Sleep in chronic obstructive pulmonary disease (COPD) is commonly associated with oxygen desaturation, which may exceed the degree of desaturation during maximum exercise, both subjectively and objectively impairing sleep quality, and management of sleep-related problems in COPD should particularly focus on minimising sleep disturbance.
Physiologic Correlates of Sleep Quality in Severe Emphysema
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Although parameters of respiratory function and mechanics correlate with sleep quality, both nocturnal oxygenation and measurements of respiratoryfunction/mechanics predict sleep quality in severe emphysema.
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References

SHOWING 1-10 OF 27 REFERENCES
The effect of controlled-release salbutamol on sleep and nocturnal oxygenation in patients with asthma and chronic obstructive pulmonary disease.
Supplemental oxygen and quality of sleep in patients with chronic obstructive lung disease.
TLDR
It is concluded that supplemental oxygen improves nocturnal oxygenation but does not immediately improve the quality of sleep in the laboratory in patients with chronic obstructive lung disease.
Sleep quality and nocturnal respiratory function with once-daily theophylline (Uniphyl) and inhaled salbutamol in patients with COPD.
TLDR
Compared with salbutamol, evening administration of once-daily theophylline results in better nocturnal oxygen saturation and an improvement in the overnight change in pulmonary function, without affecting sleep architecture, in patients with COPD.
Effect of theophylline on sleep and sleep-disordered breathing in patients with chronic obstructive pulmonary disease.
TLDR
Theophylline administration did not impair the amount or architecture of sleep as neither total sleep time nor the fraction of time spent in Stages 1, 2, and 3/4 and REM differed between the two regimens.
Effects of protriptyline on diurnal and nocturnal oxygenation in patients with chronic obstructive pulmonary disease.
TLDR
Protriptyline improves diurnal and nocturnal hypoxemia in patients with chronic obstructive pulmonary disease and shifts the cumulative SaO2 curve, derived from data obtained during sleep, down and to the right.
Theophylline improves gas exchange during rest, exercise, and sleep in severe chronic obstructive pulmonary disease.
TLDR
Theophylline has clinically significant benefits in patients with severe COPD and resulted in significantly improved pulmonary function and reduced trapped gas volume, and transcutaneous CO2 was lower during sleep.
Sleep, arousals, and oxygen desaturation in chronic obstructive pulmonary disease. The effect of oxygen therapy.
TLDR
The 95% confidence bands for arterial O2 saturation (SaO2) in the various sleep stages suggest that it is not hypoxemia per se, but an associated phenomenon such as hypercapnia that causes the arousals.
Tiotropium bromide, a new long-acting antimuscarinic bronchodilator: a pharmacodynamic study in patients with chronic obstructive pulmonary disease (COPD). Dutch Study Group.
TLDR
In this population of patients with COPD, tiotropium bromide was found to be a safe and long-acting bronchodilator, demonstrating a clear dose-response relationship following single dose administration.
The effect of oxygenation on sleep quality in chronic bronchitis and emphysema.
TLDR
Transient nocturnal hypoxemia was commonest during REM sleep in both patients and healthy subjects and its duration was not related to any sleep variable examined.
Changes in day and night time oxygenation with protriptyline in patients with chronic obstructive lung disease.
TLDR
It is suggested that protriptyline may benefit patients with chronic obstructive lung disease by reducing the sleep induced falls in SaO2 and improving diurnal PaO2; a controlled trial is now required.
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