Effect of ionic strength on length-dependent Ca(2+) activation in skinned cardiac muscle.

@article{Smith1999EffectOI,
  title={Effect of ionic strength on length-dependent Ca(2+) activation in skinned cardiac muscle.},
  author={Stephen C H Smith and Franklin Fuchs},
  journal={Journal of molecular and cellular cardiology},
  year={1999},
  volume={31 12},
  pages={2115-25}
}
The length-dependence of myofilament Ca(2+) sensitivity is considered to be an important component of the steep force-length relationship in cardiac muscle (Frank-Starling relation). Recent studies suggest that Ca(2+) sensitivity is a function of the number of strong-binding cross-bridge interactions formed at a given sarcomere length. However, the length-dependent step in the thin filament activation process is still unknown. This study was designed to test the hypothesis that sarcomere length… CONTINUE READING
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