Effect of intraventricular infusion of anti-prion protein monoclonal antibodies on disease progression in prion-infected mice.

@article{Song2008EffectOI,
  title={Effect of intraventricular infusion of anti-prion protein monoclonal antibodies on disease progression in prion-infected mice.},
  author={Chang-Hyun Song and Hidefumi Furuoka and Chan-Lan Kim and Michiko Ogino and Akio Suzuki and Rie Hasebe and Motohiro Horiuchi},
  journal={The Journal of general virology},
  year={2008},
  volume={89 Pt 6},
  pages={1533-44}
}
It is well known that anti-prion protein (PrP) monoclonal antibodies (mAbs) inhibit abnormal isoform PrP (PrPSc) formation in cell culture. Additionally, passive immunization of anti-PrP mAbs protects the animals from prion infection via peripheral challenge when mAbs are administered simultaneously or soon after prion inoculation. Thus, anti-PrP mAbs are candidates for the treatment of prion diseases. However, the effects of mAbs on disease progression in the middle and late stages of the… CONTINUE READING