Effect of intravenous lipid emulsions enriched with γ‐linolenic acid on plasma n‐6 fatty acids and prostaglandin biosynthesis after burn and endotoxin injury in rats

  title={Effect of intravenous lipid emulsions enriched with $\gamma$‐linolenic acid on plasma n‐6 fatty acids and prostaglandin biosynthesis after burn and endotoxin injury in rats},
  author={Michael D. Karlstad and Stephen J. Demichele and W D Leathem and Myron B. Peterson},
  journal={Critical Care Medicine},
Objective:To study the effect of intravenous lipid emulsions enriched with γ-linolenic acid on plasma fatty acids and series-2 prostaglandins to determine if the slow conversion of linoleic acid by Δ-6-desaturase to γ-linolenic acid could be bypassed to provide substrate for the formation of dihomo-γ-linolenic acid, the immediate precursor for series-1 prostaglandins, in control and injured rats. Dihomo-γ-linolenic acid can also compete with arachidonic acid for oxidative metabolism by… Expand
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Free fatty acids (FFA) are known to interfere with glucose metabolism. Moreover, it has been shown that they are able to impair the endothelium-dependent vasodilation. Therefore, we sought toExpand