Effect of intravenous ketanserin on the human action potential duration at fixed heart rate

  title={Effect of intravenous ketanserin on the human action potential duration at fixed heart rate},
  author={Angela J. Drake-Holland and Mark I. M. Noble and Sara Pugh and Christopher Mills},
  journal={Cardiovascular Drugs and Therapy},
In this study any changes in action potential duration or Q-T interval due to acute doses of ketanserin were monitored. The effect of a bolus dose (10 or 20 mg) followed by an infusion (10 or 20 mg over 20 minutes) of ketanserin on the Q-T interval and action potential duration was studied in six patients undergoing routine cardiac catheterization. Action potential duration was measured with a silver-silver chloride electrode catheter while heart rate was kept constant by atrial pacing and… CONTINUE READING

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Clinical Aspects of Ventricular Repolarization , International Conference on the Management of Cardiac Arrythmias

  • Miller GAH, Noble MIM, D Papadoyannis
  • PACE
  • 1987

Clinical pharmacology of ketanserin

  • SG Ball
  • 1986

Serotonin mechanisms in the cardiovascular system

  • PM Vanhoutte, A Amery, eds
  • J Cardiovasc Pharmacol 1985; 7(Suppl
  • 1985

A classification of heart serotonin receptors (abstr)

  • AJ Kauman
  • Naunyn Schmiedebergs Arch Pharmacol
  • 1983

Modulation of myocardial membrane function: Phosphorylation of membrane proteins

  • AJ Drake-Holland, MM Noble
  • 1983

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