Effect of intravenous ketanserin on the human action potential duration at fixed heart rate

@article{DrakeHolland1988EffectOI,
  title={Effect of intravenous ketanserin on the human action potential duration at fixed heart rate},
  author={Angela J. Drake-Holland and Mark I. M. Noble and Sara Pugh and Christopher Mills},
  journal={Cardiovascular Drugs and Therapy},
  year={1988},
  volume={2},
  pages={239-243}
}
In this study any changes in action potential duration or Q-T interval due to acute doses of ketanserin were monitored. The effect of a bolus dose (10 or 20 mg) followed by an infusion (10 or 20 mg over 20 minutes) of ketanserin on the Q-T interval and action potential duration was studied in six patients undergoing routine cardiac catheterization. Action potential duration was measured with a silver-silver chloride electrode catheter while heart rate was kept constant by atrial pacing and… CONTINUE READING

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