Effect of intravenous corticosteroids on death within 14 days in 10 008 adults with clinically significant head injury (MRC CRASH trial): randomised placebo-controlled trial

@article{Roberts2004EffectOI,
  title={Effect of intravenous corticosteroids on death within 14 days in 10 008 adults with clinically significant head injury (MRC CRASH trial): randomised placebo-controlled trial},
  author={I. Roberts and D. Yates and P. Sandercock and B. Farrell and J. Wasserberg and G. Lomas and R. Cottingham and P. Svoboda and N. Brayley and G. Mazairac and V. Lalo{\"e} and A. Mu{\~n}oz-S{\'a}nchez and M. Arango and B. Hartzenberg and H. Khamis and Surakrant Yutthakasemsunt and E. Komolafe and F. Olldashi and Y. Yadav and F. Murillo-Cabezas and H. Shakur and P. Edwards},
  journal={The Lancet},
  year={2004},
  volume={364},
  pages={1321-1328}
}
BACKGROUND Corticosteroids have been used to treat head injuries for more than 30 years. In 1997, findings of a systematic review suggested that these drugs reduce risk of death by 1-2%. The CRASH trial--a multicentre international collaboration--aimed to confirm or refute such an effect by recruiting 20000 patients. In May, 2004, the data monitoring committee disclosed the unmasked results to the steering committee, which stopped recruitment. METHODS 10008 adults with head injury and a… Expand
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