Effect of intravenous N-acetylcysteine on outcomes after coronary artery bypass surgery: a randomized, double-blind, placebo-controlled clinical trial.

@article{ElHamamsy2007EffectOI,
  title={Effect of intravenous N-acetylcysteine on outcomes after coronary artery bypass surgery: a randomized, double-blind, placebo-controlled clinical trial.},
  author={Ismail El-Hamamsy and Rodney L. Stevens and M. Zachariah M. Carrier and Michel Pellerin and Denis Bouchard and Philippe Demers and Raymond Cartier and Pierre Pag{\'e} and Louis P Perrault},
  journal={The Journal of thoracic and cardiovascular surgery},
  year={2007},
  volume={133 1},
  pages={
          7-12
        }
}
OBJECTIVE N-acetylcysteine, a potent anti-inflammatory and antioxidant agent, is known to decrease the production of reactive oxygen species after cardiac surgery. The objective of this study was to evaluate the effects of intravenous N-acetylcysteine on clinical and biochemical outcomes after coronary artery bypass surgery with cardiopulmonary bypass. METHODS One hundred patients (mean age 60.5 years, range 43-78 years, 89% male) undergoing coronary artery bypass grafting at the Montreal… CONTINUE READING
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