Effect of intrathecally administered noradrenergic antagonists on nociception in the rat.

@article{Sagen1984EffectOI,
  title={Effect of intrathecally administered noradrenergic antagonists on nociception in the rat.},
  author={Jacqueline Sagen and Herbert K Proudfit},
  journal={Brain research},
  year={1984},
  volume={310 2},
  pages={295-301}
}
Recent evidence suggests that some groups of noradrenergic neurons found in the brainstem have axonal connections in the spinal cord dorsal horn and may be involved in the control of pain sensitivity. Such evidence includes the demonstration that intrathecal injection of noradrenergic agonists increases nociceptive threshold (hypoalgesia). The present studies examined whether the descending noradrenergic system is tonically active and, if so, what noradrenergic receptor subtypes mediate the… CONTINUE READING