Effect of intrathecal tizanidine on antinociception and blood pressure in the rat

@article{McCarthy1990EffectOI,
  title={Effect of intrathecal tizanidine on antinociception and blood pressure in the rat},
  author={Robert J. McCarthy and Jeffrey S. Kroin and Timothy R. Lubenow and Richard D. Penn and Anthony D. Ivankovich},
  journal={Pain},
  year={1990},
  volume={40},
  pages={333-338}
}
Experiments were performed in rats to determine if the alpha 2-adrenergic agonist tizanidine has an antinociceptive effect when injected intrathecally, and whether the analgesia is accompanied by changes in blood pressure. Rats were chronically implanted with catheters in the lumbar subarachnoid space. Antinociception was evaluated in conscious rats with the tail-flick test. Increasing tizanidine doses produced increases in analgesic efficacy, with 25 micrograms producing a significant long… CONTINUE READING

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