Effect of intraperitoneal injection of sulodexide on peritoneal function and albumin leakage in continuous ambulatory peritoneal dialysis patients.

@article{Guedri2016EffectOI,
  title={Effect of intraperitoneal injection of sulodexide on peritoneal function and albumin leakage in continuous ambulatory peritoneal dialysis patients.},
  author={Yosra Guedri and K Najla Damma and Melek Toumi and Wissal Sahtout and Awatef Azzabi and Sinda Mrabet and Safa Nouira and Dalila Saidane and Samira Amor and Anis Belarbia and Dorsaf Zellama and Abdellatif Achour},
  journal={Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia},
  year={2016},
  volume={27 6},
  pages={
          1194-1199
        }
}
  • Y. Guedri, K. N. Damma, A. Achour
  • Published 1 November 2016
  • Medicine, Biology
  • Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia
Peritoneal protein loss is one of the inevitable consequences during continuous ambulatory peritoneal dialysis (CAPD). Our objective was to study the effect of sulodexide on the protein loss and efficiency of dialysis. This study included six patients receiving CAPD treated with sulodexide at the dose of 600 IU/day given by intraperitoneal injection for 10 days. Clinical and biologic parameters were assessed before starting the treatment (D0 and after 10 days of treatment (D10. We also… 
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References

Oral sulodexide reduces albuminuria in microalbuminuric and macroalbuminuric type 1 and type 2 diabetic patients: the Di.N.A.S. randomized trial.
TLDR
A 4-mo course of high doses of sulodexide significantly and dose-dependently improves albuminuria in DM1 and DM2 patients and micro- or macroalbuminuric patients with or without concomitant ACE inhibition.