Effect of intramuscular cholecalciferol megadose in children with nutritional rickets

@article{Bothra2016EffectOI,
  title={Effect of intramuscular cholecalciferol megadose in children with nutritional rickets},
  author={Meenakshi Bothra and Nandita Gupta and Vandana Jain},
  journal={Journal of Pediatric Endocrinology and Metabolism},
  year={2016},
  volume={29},
  pages={687 - 692}
}
Abstract Background: The treatment practices for vitamin D deficiency rickets are highly variable. Though a single intramuscular (IM) megadose of vitamin D is economical, and ensures good compliance, it poses the risk of hypervitaminosis D. This observational study was conducted to assess the duration of effect and safety of single IM megadose of cholecalciferol in the treatment of vitamin D deficiency rickets. Methods: Children younger than 14 years with rickets were enrolled. Baseline… Expand
6 Citations
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Two patients with renal lithiasis who received a megadose of 25-hydroxy vitamin D (25[OH]D) and had a good outcome are described, to the best of the authors' knowledge this is the first description of a megADose of vitamin D used in patients without hyper-hygiene, and shows the safety of this vitamin every 4 mo. Expand
Low Dose Depot Oral Vitamin D3 Versus Daily Oral Vitamin D3 for Treating Nutritional Rickets: A Randomized Clinical Trial.
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Low dose oral depot vitamin D3 is an effective alternative to daily oralitamin D3 for nutritional rickets and shows a significant improvement in all biochemical parameters as well as radiological healing. Expand
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There is a global secular trend of increases in 25-OHD over years and empirical, unmonitored, prolonged vitamin D supplementation, using non-recommended supraphysiological doses, especially when administered intramuscularly, should be discouraged. Expand
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An expert panel of the Italian Society of Preventive and Social Pediatrics reviewed available literature focusing on randomized controlled trials of vitamin D supplements to provide a practical approach to vitamin D supplementation for infants, children and adolescents. Expand
RICKETS, VITAMIN D DEFICIENCY, AND GLOBAL CONSENSUS RECOMMENDATIONS ON PREVENTION AND MANAGEMENT OF NUTRITIONAL RICKETS: RUSSIAN PEDIATRICIANS’ OPINION
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Positive and negative aspects of these Consensus recommendations are reviewed and carped when necessary and the need for the development of Russian national consensus on rickets prevention and management is noted. Expand
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A review of reports of vitamin D intoxication in the general population highlights that the majority of cases were preventable and discusses the inappropriate use of poorly formulated, and unlicensed vitamin D preparations. Expand

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