Effect of intramuscular cholecalciferol megadose in children with nutritional rickets

  title={Effect of intramuscular cholecalciferol megadose in children with nutritional rickets},
  author={Meenakshi Bothra and Nandita Gupta and Vandana Jain},
  journal={Journal of Pediatric Endocrinology and Metabolism},
  pages={687 - 692}
Abstract Background: The treatment practices for vitamin D deficiency rickets are highly variable. Though a single intramuscular (IM) megadose of vitamin D is economical, and ensures good compliance, it poses the risk of hypervitaminosis D. This observational study was conducted to assess the duration of effect and safety of single IM megadose of cholecalciferol in the treatment of vitamin D deficiency rickets. Methods: Children younger than 14 years with rickets were enrolled. Baseline… Expand
6 Citations
Safety of megadose of vitamin D in patients with nephrolithiasis.
Two patients with renal lithiasis who received a megadose of 25-hydroxy vitamin D (25[OH]D) and had a good outcome are described, to the best of the authors' knowledge this is the first description of a megADose of vitamin D used in patients without hyper-hygiene, and shows the safety of this vitamin every 4 mo. Expand
Low Dose Depot Oral Vitamin D3 Versus Daily Oral Vitamin D3 for Treating Nutritional Rickets: A Randomized Clinical Trial.
Low dose oral depot vitamin D3 is an effective alternative to daily oralitamin D3 for nutritional rickets and shows a significant improvement in all biochemical parameters as well as radiological healing. Expand
The increasing problem of subclinical and overt hypervitaminosis D in India: An institutional experience and review.
There is a global secular trend of increases in 25-OHD over years and empirical, unmonitored, prolonged vitamin D supplementation, using non-recommended supraphysiological doses, especially when administered intramuscularly, should be discouraged. Expand
Vitamin D in pediatric age: consensus of the Italian Pediatric Society and the Italian Society of Preventive and Social Pediatrics, jointly with the Italian Federation of Pediatricians
An expert panel of the Italian Society of Preventive and Social Pediatrics reviewed available literature focusing on randomized controlled trials of vitamin D supplements to provide a practical approach to vitamin D supplementation for infants, children and adolescents. Expand
Positive and negative aspects of these Consensus recommendations are reviewed and carped when necessary and the need for the development of Russian national consensus on rickets prevention and management is noted. Expand
A review of the growing risk of vitamin D toxicity from inappropriate practice
A review of reports of vitamin D intoxication in the general population highlights that the majority of cases were preventable and discusses the inappropriate use of poorly formulated, and unlicensed vitamin D preparations. Expand


Manifestations of severe vitamin D deficiency in adolescents: effects of intramuscular injection of a megadose of cholecalciferol.
Two patterns of radiological changes have been recorded with complete healing achieved in all patients after a year of therapy and a mega dose of cholecalciferol is an effective therapy for treatment of VDD in adolescents. Expand
Response of a single 'mega intramuscular dose' of vitamin D on serum 25OHD and parathyroid hormone levels.
A single mega-dose of cholecalciferol achieved optimal levels of 25OHD in 35% of subjects after eight weeks of supplementation and showed a significant inverse correlation at baseline and at follow-up. Expand
Resurrection of vitamin D deficiency and rickets.
  • M. Holick
  • Medicine
  • The Journal of clinical investigation
  • 2006
This review summarizes the role of vitamin D in the prevention of rickets and its importance in the overall health and welfare of infants and children. Expand
Comparison of Low and High Dose of Vitamin D Treatment in Nutritional Vitamin D Deficiency Rickets
It was showed that 150,000 IU or 300,000IU of vitamin D was adequate in the treatment of VDR, but 600,000 Bloomington's D may carry the risk of hypercalcemia. Expand
Vitamin D level in slum children of Delhi.
A study looking at the 25 (OH) D levels in slum children from three areas in Delhi and found evidence of widespread vitamin D deficiency. Expand
Therapy strategies in vitamin D deficiency with or without rickets: efficiency of low-dose stoss therapy
Vitamin D levels at the end of stoss therapy were significantly increased compared with daily lower-dose vitamin D therapy group (p<0.001); there was no evidence about the increasing risk of hypercalciuria in low-stoss therapy. Expand
300,000 IU or 600,000 IU of oral vitamin D3 for treatment of nutritional rickets: A randomized controlled trial
A dose of 300,000 IU of vitamin D3 is comparable to 600,000IU, administered orally, over a single day, for treating rickets in under-five children although there is an unacceptably high risk of hypercalcemia in both groups. Expand
Vitamin D supplementation and risk of toxicity in pediatrics: a review of current literature.
The Drugs and Therapeutics Committee of the Pediatric Endocrine Society suggests obtaining serum 25-hydroxyvitamin D levels in infants and children who receive long-term vitamin D supplementation at or above the upper level intake that is currently recommended. Expand
Intermittent high-dose vitamin D prophylaxis during infancy: effect on vitamin D metabolites, calcium, and phosphorus.
In infants receiving intermittent high dose vitamin D prophylaxis every 3-5 mo, the serum concentrations of vitamin D metabolites, calcium (Ca), and phosphorus (P) were determined before and 2 wk after each dose, indicating that the vitamin D doses were excessive despite the lack of accumulative increases in serum vitamin D concentrations. Expand
A Randomized controlled trial on safety and efficacy of single intramuscular versus staggered oral dose of 600 000IU Vitamin D in treatment of nutritional rickets.
Staggered oral and one-time intramuscular administrations of 600 000IU vitamin D are equally effective and safe in treatment of nutritional rickets. Expand