Effect of intramuscular cholecalciferol megadose in children with nutritional rickets

@article{Bothra2016EffectOI,
  title={Effect of intramuscular cholecalciferol megadose in children with nutritional rickets},
  author={Meenakshi Bothra and Nandita Gupta and Vandana Jain},
  journal={Journal of Pediatric Endocrinology and Metabolism},
  year={2016},
  volume={29},
  pages={687 - 692}
}
Abstract Background: The treatment practices for vitamin D deficiency rickets are highly variable. Though a single intramuscular (IM) megadose of vitamin D is economical, and ensures good compliance, it poses the risk of hypervitaminosis D. This observational study was conducted to assess the duration of effect and safety of single IM megadose of cholecalciferol in the treatment of vitamin D deficiency rickets. Methods: Children younger than 14 years with rickets were enrolled. Baseline… Expand
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6 Citations

6 Citations

Citation Type

Citation Type

Safety of megadose of vitamin D in patients with nephrolithiasis.
TLDR
Two patients with renal lithiasis who received a megadose of 25-hydroxy vitamin D (25[OH]D) and had a good outcome are described, to the best of the authors' knowledge this is the first description of a megADose of vitamin D used in patients without hyper-hygiene, and shows the safety of this vitamin every 4 mo. Expand
Low Dose Depot Oral Vitamin D3 Versus Daily Oral Vitamin D3 for Treating Nutritional Rickets: A Randomized Clinical Trial.
TLDR
Low dose oral depot vitamin D3 is an effective alternative to daily oralitamin D3 for nutritional rickets and shows a significant improvement in all biochemical parameters as well as radiological healing. Expand
The increasing problem of subclinical and overt hypervitaminosis D in India: An institutional experience and review.
TLDR
There is a global secular trend of increases in 25-OHD over years and empirical, unmonitored, prolonged vitamin D supplementation, using non-recommended supraphysiological doses, especially when administered intramuscularly, should be discouraged. Expand
Vitamin D in pediatric age: consensus of the Italian Pediatric Society and the Italian Society of Preventive and Social Pediatrics, jointly with the Italian Federation of Pediatricians
TLDR
An expert panel of the Italian Society of Preventive and Social Pediatrics reviewed available literature focusing on randomized controlled trials of vitamin D supplements to provide a practical approach to vitamin D supplementation for infants, children and adolescents. Expand
RICKETS, VITAMIN D DEFICIENCY, AND GLOBAL CONSENSUS RECOMMENDATIONS ON PREVENTION AND MANAGEMENT OF NUTRITIONAL RICKETS: RUSSIAN PEDIATRICIANS’ OPINION
TLDR
Positive and negative aspects of these Consensus recommendations are reviewed and carped when necessary and the need for the development of Russian national consensus on rickets prevention and management is noted. Expand
A review of the growing risk of vitamin D toxicity from inappropriate practice
TLDR
A review of reports of vitamin D intoxication in the general population highlights that the majority of cases were preventable and discusses the inappropriate use of poorly formulated, and unlicensed vitamin D preparations. Expand

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