Effect of intramammary infusion of tumour necrosis factor-alpha on milk protein composition and induction of acute-phase protein in the lactating cow.

@article{Watanabe2000EffectOI,
  title={Effect of intramammary infusion of tumour necrosis factor-alpha on milk protein composition and induction of acute-phase protein in the lactating cow.},
  author={Atsushi Watanabe and Yukio Yagi and Hiroki Shiono and Yuichi Yokomizo},
  journal={Journal of veterinary medicine. B, Infectious diseases and veterinary public health},
  year={2000},
  volume={47 9},
  pages={653-62}
}
The present study was designed to evaluate the effects of tumour necrosis factor-alpha (TNF-alpha) on lactating bovine mammary functions such as milk protein secretion and the integrity of the milk-blood barrier. The effect on the induction of the systemic inflammatory response was also examined using concentrations of serum haptoglobin (Hp), a major inflammatory acute-phase protein, as an index. One hundred micrograms per mammary gland of recombinant bovine (rBo) TNF-alpha or placebo saline… CONTINUE READING