Effect of intraluteal injection of endothelin type A receptor antagonist on PGF2alpha-induced luteolysis in the cow.

@article{Watanabe2006EffectOI,
  title={Effect of intraluteal injection of endothelin type A receptor antagonist on PGF2alpha-induced luteolysis in the cow.},
  author={Sho Watanabe and Koumei Shirasuna and Motozumi Matsui and Dai Yamamoto and Bajram Berisha and Dieter Schams and Akio Miyamoto},
  journal={The Journal of reproduction and development},
  year={2006},
  volume={52 4},
  pages={551-9}
}
Endothelin-1 (ET-1) is a luteolytic mediator in the bovine corpus luteum (CL), and its action appears to be via endothelin type A receptor (ETR-A). Thus, the aim of the present study was to determine the effect of ETR-A antagonist on PGF2alpha-induced luteolysis in the cow. Cows on days 10-12 of the estrous cycle were subjected to five intraluteal injections of the ETR-A antagonist LU 135252 in saline or only saline at -0.5, 2, 4, 6, and 8 h after PGF2alpha administration (=0 h). Serial luteal… CONTINUE READING

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