Effect of intragastric and intraperitoneal immunisation with attenuated and wild-type LACK-expressing Listeria monocytogenes on control of murine Leishmania major infection.

@article{Soussi2002EffectOI,
  title={Effect of intragastric and intraperitoneal immunisation with attenuated and wild-type LACK-expressing Listeria monocytogenes on control of murine Leishmania major infection.},
  author={Neirouz Soussi and H{\'e}l{\`e}ne Saklani-Jusforgues and Jean Herv{\'e} Colle and Genevi{\`e}ve Milon and Nicolas Glaichenhaus and P. Goossens},
  journal={Vaccine},
  year={2002},
  volume={20 21-22},
  pages={2702-12}
}
Stable chromosomal constructs of attenuated DeltaactA and wild-type Listeria monocytogenes expressing the Leishmania major protein LACK were tested as live vaccine vectors in the Th2-orientated chronic L. major murine infection model. These vectors, either by intraperitoneal (i.p.) or intragastric (i.g.) route, were able to induce a strong CD4 Th1 immune response that was correlated with slower parasite growth in the infected footpad. Significant protection against L. major infection was… CONTINUE READING

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