Effect of intracellular acidification on colonic NaCl absorption.

@article{Dagher1993EffectOI,
  title={Effect of intracellular acidification on colonic NaCl absorption.},
  author={Pierre C Dagher and Richard W Egnor and Alan N. Charney},
  journal={The American journal of physiology},
  year={1993},
  volume={264 3 Pt 1},
  pages={G569-75}
}
CO2 stimulates Na+ and Cl- absorption in rat distal colon. This is most likely due to intracellular generation of H+ and HCO3- and stimulation of apical Na(+)-H+ and Cl(-)-HCO3- exchangers. We examined whether intracellular acidification by means other than CO2 would also stimulate Na+ absorption. Stripped segments of distal colon from male Sprague-Dawley rats were studied under short-circuit conditions in Ussing chambers. Identically prepared tissues were used for intracellular pH (pHi… CONTINUE READING

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