Effect of intraarterial versus intravenous cisplatin in addition to systemic doxorubicin, high-dose methotrexate, and ifosfamide on histologic tumor response in osteosarcoma (study COSS-86).

@article{Winkler1990EffectOI,
  title={Effect of intraarterial versus intravenous cisplatin in addition to systemic doxorubicin, high-dose methotrexate, and ifosfamide on histologic tumor response in osteosarcoma (study COSS-86).},
  author={Kurt Winkler and Stefan S. Bielack and Guenter Delling and Mechthild Salzer-Kuntschik and Rainer Kotz and C Greenshaw and Heribert J{\"u}rgens and Joerg Ritter and Claus R. Kusnierz-Glaz and Rudolf Erttmann},
  journal={Cancer},
  year={1990},
  volume={66 8},
  pages={1703-10}
}
In osteosarcoma, intraarterial (IA) administration of systemic treatment has been advocated to improve local tumor response preparing for, or even obviating, definitive surgery. Because data from the literature did not unequivocally support the local superiority of IA infusion, a comparative study was started in 1986. Preoperative chemotherapy consisted of 45 mg/m2 of doxorubicin on days 1 and 2; 12 g/m2 of high-dose methotrexate on days 15 and 22; and 3 g/m2 of ifosfamide on days 29, 30, 50… CONTINUE READING

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