Effect of intestinal microbiota on the induction of regulatory CD25+ CD4+ T cells.

  title={Effect of intestinal microbiota on the induction of regulatory CD25+ CD4+ T cells.},
  author={Hajime Ishikawa and Keiji Tanaka and Yoshihiko Maeda and Yoshihiro Aiba and Akihiro Hata and Noriko M. Tsuji and Yasuhiko Koga and Toshio Matsumoto},
  journal={Clinical and experimental immunology},
  volume={153 1},
When oral tolerance was induced in either specific pathogen-free (SPF) or germ-free (GF) mice, ovalbumin (OVA) feeding before immunization induced oral tolerance successfully in SPF mice. On the other hand, OVA-specific immunoglobulin G1 (IgG1) and IgE titres in OVA-fed GF mice were comparable to those in phosphate-buffered saline-fed GF mice, thus demonstrating that oral tolerance could not be induced in GF mice. The frequencies of CD25(+) CD4(+)/CD4(+) cells in the mesenteric lymph node (MLN… CONTINUE READING


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