Effect of intestinal hormones on pentagastrin- and histamine-evoked gastric acid secretion and duodenal ulcerations in cats

@article{Konturek2005EffectOI,
  title={Effect of intestinal hormones on pentagastrin- and histamine-evoked gastric acid secretion and duodenal ulcerations in cats},
  author={S. Konturek and T. Radecki and P. Thor and N. Kwiecień},
  journal={The American Journal of Digestive Diseases},
  year={2005},
  volume={18},
  pages={135-141}
}
In conscious cats with gastric fistulae and the diversion of bile and pancreatic juice to jejunum, secretin (1 unit/kg-hr), cholecystokinin (CCK) (4 units/kg-hr), and duodenal acidification (1 mEq HCl/hr) caused a marked inhibition of half maximal gastric acid response to pentagastrin (8 μg/kg-hr) but did not alter the response to histamine (160 μg/kg-hr). Secretin, CCK, and jejunal acidification prevented the formation of duodenal ulcerations in conscious cats infused with pentagastrin or… Expand
Effects of secretin on content of PGE2 and 6-keto PGF1α in gastric mucosa

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