Effect of interleukin 11 on normal and pathological thrombopoiesis

  title={Effect of interleukin 11 on normal and pathological thrombopoiesis},
  author={Masanao Teramura and Shoko Kobayashi and Kentaro Yoshinaga and Koji Iwabe and Hideaki Mizoguchi},
  journal={Cancer Chemotherapy and Pharmacology},
 Interleukin 11 (IL-11) is a stromal cell-derived cytokine that has multiple effects on hematopoietic and nonhematopoietic systems. In vitro, it enhances the growth of early progenitors and promotes megakaryocytopoiesis and erythropoiesis. In healthy animals, IL-11 administration stimulates megakaryocyte maturation and increases peripheral platelet counts. IL-11 accelerates the recovery of peripheral neutrophil, erythrocyte, and platelet counts in mice that have undergone cytoablative treatment… CONTINUE READING