Effect of interleukin-1 beta on airway hyperresponsiveness and inflammation in sensitized and nonsensitized Brown-Norway rats.

@article{Tsukagoshi1994EffectOI,
  title={Effect of interleukin-1 beta on airway hyperresponsiveness and inflammation in sensitized and nonsensitized Brown-Norway rats.},
  author={Hideo Tsukagoshi and Tatsuo Sakamoto and Wen-bing Xu and Peter J Barnes and Kian Fan Chung},
  journal={The Journal of allergy and clinical immunology},
  year={1994},
  volume={93 2},
  pages={464-9}
}
Airway responsiveness (AR) to inhaled acetylcholine and bradykinin and inflammatory cell recruitment in bronchoalveolar lavage fluid (BALF) were studied in inbred male Brown-Norway rats actively sensitized to ovalbumin and later given 500 U interleukin-1 beta (IL-1 beta) intratracheally. We examined animals 14 to 21 days after initial sensitization at 18 to 24 hours after the intratracheal administration of IL-1 beta. We evaluated AR to acetylcholine as -log PC200, which is -log10… CONTINUE READING