Effect of interleukin-1 beta converting enzyme inhibitor on acute myelogenous leukemia progenitor proliferation.

@article{Estrov1995EffectOI,
  title={Effect of interleukin-1 beta converting enzyme inhibitor on acute myelogenous leukemia progenitor proliferation.},
  author={Zeev E Estrov and Roy A. Black and Paul R. Sleath and David M Harris and Quin Van and Ruth Lapushin and Elihu H Estey and Moshe Talpaz},
  journal={Blood},
  year={1995},
  volume={86 12},
  pages={
          4594-602
        }
}
Interleukin-1 beta (IL-1 beta) converting enzyme (ICE) is a cysteine protease that specifically cleaves precursor IL-1 beta to its biologically active form. Recent studies have also implicated ICE in the induction of apoptosis in vertebrate cells. Because IL-1 plays a major role in acute myelogenous leukemia (AML) blast proliferation, we sought to investigate the effect of ICE inhibition on AML progenitors. To do this, we used bocaspartyl (benzyl) chloromethylketone (BACMK) an inhibitor… 

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