Effect of interleukin-1 beta, tumour necrosis factor-alpha and interferon-gamma on the induction of cyclo-oxygenase-2 in cultured human airway smooth muscle cells.


1. Increased levels of several pro-inflammatory cytokines including interleukin-1 beta (IL-1 beta) and tumour necrosis factor-alpha (TNF alpha) have been found in bronchoalveolar lavage fluid from symptomatic asthmatic patients. IL-1 beta, TNF alpha and interferon-gamma (IFN gamma) are known to stimulate a number of cells to produce inflammatory mediators… (More)


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