Effect of interferon beta-1a on B7.1 and B7.2 B-cell expression and its impact on T-cell proliferation.

@article{Huang2013EffectOI,
  title={Effect of interferon beta-1a on B7.1 and B7.2 B-cell expression and its impact on T-cell proliferation.},
  author={Hui Huang and Kouichi Ito and Fernando Dangond and Suhayl Dhib-Jalbut},
  journal={Journal of neuroimmunology},
  year={2013},
  volume={258 1-2},
  pages={27-31}
}
The effect of pharmacologically relevant doses of interferon (IFN) β-1a on B-cell expression of B7.1 and B7.2 was investigated. Culture of peripheral blood mononuclear cells with IFN β-1a 100 IU/mL decreased B-cell expression of B7.1 and increased B7.2 expression. Interleukin-10 in B cells was significantly enhanced by IFN β-1a. Anti-CD3 and anti-CD28 monoclonal antibody-mediated T-cell proliferations were partially suppressed in the presence of B cells pretreated with IFN β-1a. These data… CONTINUE READING