Effect of interferon and double-stranded RNA on B-cell function in mouse islets of Langerhans.

@article{Rhodes1985EffectOI,
  title={Effect of interferon and double-stranded RNA on B-cell function in mouse islets of Langerhans.},
  author={Christopher J Rhodes and Keith Weller Taylor},
  journal={The Biochemical journal},
  year={1985},
  volume={228 1},
  pages={
          87-94
        }
}
The direct effects of alpha- and beta-interferons on isolated mouse pancreatic islets were investigated in vitro and found to be similar. After 7 h incubation with interferon concentrations above 350 units/ml, glucose-stimulated (pro)insulin biosynthesis was significantly inhibited, with only a slight inhibition of total protein biosynthesis. Inhibition could be abolished in the additional presence of an anti-interferon antibody. Interferon did not affect insulin release, total insulin content… CONTINUE READING