Effect of interferon-alpha on DOI-induced wet-dog shakes in rats.

@article{Kugaya1996EffectOI,
  title={Effect of interferon-alpha on DOI-induced wet-dog shakes in rats.},
  author={Akira Kugaya and Ariyuki Kagaya and Yosuke Uchitomi and Naoko Yokota and Sbigeto Yamawaki},
  journal={Journal of neural transmission},
  year={1996},
  volume={103 8-9},
  pages={947-55}
}
Acute (1 h) intraperitoneal (i.p.) treatment with interferon (IFN)-alpha-2a (300 IU/g) significantly inhibited wet-dog shakes (WDS) induced by (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2 aminopropane (DOI; 0.5, 1.0 mg/kg), which is mediated by serotonin (5-hydroxytryptamine; 5-HT)2 receptor in rats. IFN-alpha did not affect spontaneous locomotion. The inhibition of DOI (0.5 mg/kg)-induced WDS by IFN-alpha was dose (90-300 IU/g)- and time (1-6 h)-dependent, and was prevented by 30 min pretreatment… CONTINUE READING