Effect of interdomain dynamics on the structure determination of modular proteins by small-angle scattering


Multidomain proteins in which consecutive globular regions are connected by linkers are prevalent in nature (Levitt in Proc Natl Acad Sci USA 106:11079–11084, 2009). Some members of this family have largely resisted structural characterization as a result of challenges associated with their inherent flexibility. Small-angle scattering (SAS) is often the… (More)
DOI: 10.1007/s00249-009-0549-3


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