Effect of intensive insulin therapy on beta-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes: a multicentre randomised parallel-group trial.

@article{Weng2008EffectOI,
  title={Effect of intensive insulin therapy on beta-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes: a multicentre randomised parallel-group trial.},
  author={Jianping Weng and Yanbing Li and Wen Xu and Lixin Shi and Qiao Zhang and Dalong Zhu and Yun Yu Hu and Zhiguang Zhou and Xiang Yan and Hao-ming Tian and Xingwu Ran and Zuojie Luo and Jing Xian and Li Yan and Fangping Li and Longyi Zeng and Yanming Chen and Liyong Yang and Sunjie Yan and Juan Liu and Ming Li and Zuzhi Fu and Hua Cheng},
  journal={Lancet},
  year={2008},
  volume={371 9626},
  pages={1753-60}
}
BACKGROUND Early intensive insulin therapy in patients with newly diagnosed type 2 diabetes might improve beta-cell function and result in extended glycaemic remissions. We did a multicentre, randomised trial to compare the effects of transient intensive insulin therapy (continuous subcutaneous insulin infusion [CSII] or multiple daily insulin injections [MDI]) with oral hypoglycaemic agents on beta-cell function and diabetes remission rate. METHODS 382 patients, aged 25-70 years, were… CONTINUE READING
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