Effect of insulin immunization on glucose tolerance in normal rats.

@article{Froguel1987EffectOI,
  title={Effect of insulin immunization on glucose tolerance in normal rats.},
  author={Ph. Froguel and G{\'e}rard Reach},
  journal={Diabete & metabolisme},
  year={1987},
  volume={13 5},
  pages={508-13}
}
Normal rats were immunized with insulin and Freund's adjuvant and submitted to an intravenous glucose tolerance test. Plasma glucose and free and total IRI levels were determined and compared to those observed in untreated rats, and in animals injected with the Freund's adjuvant used for the immunization procedure. In six of the 15 insulin injected animals, a significant amount of IRI (more than 100 mU/l) was found to circulate in bound form. In these animals, the fasting plasma glucose… CONTINUE READING