Effect of insulin and contraction up on glucose transport in skeletal muscle.

@article{Pereira2004EffectOI,
  title={Effect of insulin and contraction up on glucose transport in skeletal muscle.},
  author={Luciana Oquendo Pereira and Antonio Herbert Jr. Lancha},
  journal={Progress in biophysics and molecular biology},
  year={2004},
  volume={84 1},
  pages={
          1-27
        }
}
The major glucose transporter protein expressed in skeletal muscle is GLUT4. Both muscle contraction and insulin induce translocation of GLUT4 from the intracellular pool to the plasma membrane. The intracellular pathways that lead to contraction- and insulin-stimulated GLUT4 translocation seem to be different, allowing the attainment of a maximal effect when acting together. Insulin utilizes a phosphatidylinositol 3-kinase-dependent mechanism, whereas the exercise signal may be initiated by… Expand
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