• Corpus ID: 25936886

Effect of inositol hexaphosphate on the development of UVB-induced skin tumors in SKH1 hairless mice.

  title={Effect of inositol hexaphosphate on the development of UVB-induced skin tumors in SKH1 hairless mice.},
  author={Krishnan Kolappaswamy and Kendra A. Williams and Cinzia Benazzi and Giuseppe Sarli and Charles G. McLeod and Ivana Vucenik and Louis J Detolla},
  journal={Comparative medicine},
  volume={59 2},
Inositol hexaphosphate (IP6) is a naturally occurring polyphosphorylated carbohydrate that is abundant in many plants and in various high-fiber foods, such as cereals and legumes. IP6 has a striking, broad-spectrum anticancer activity in various in vitro and animal models, in which it interferes with key pathways in malignancy to inhibit cell proliferation, cell-cycle progression, metastasis, invasion, and angiogenesis and to induce apoptosis. In this study, we investigated the protective… 

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