Effect of inorganic fluoride on the renal concentrating mechanism. Possible nephrotoxicity in man.

@article{Frascino1972EffectOI,
  title={Effect of inorganic fluoride on the renal concentrating mechanism. Possible nephrotoxicity in man.},
  author={J. Frascino},
  journal={The Journal of laboratory and clinical medicine},
  year={1972},
  volume={79 2},
  pages={
          192-203
        }
}
  • J. Frascino
  • Published 1972
  • Chemistry, Medicine
  • The Journal of laboratory and clinical medicine
  • Abstract It has been proposed that the renal defect in water conservation occurring after administration of methoxyflurane anesthesia may be due to a nephrotoxic effect of inorganic fluoride released during metabolic degradation of the anesthetic. To investigate this possibility, the effects of inorganic fluoride (NaF) on CH 2 O, TcH 2 O, Umax and corticomedullary sodium gradient were studied in the dog. During steady state 10 per cent mannitol diuresis, intravenous infusion of NaF at 4 to 5 mg… CONTINUE READING

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