Effect of inhibitors of Na+/H+-exchange and gastric H+/K+ ATPase on cell volume, intracellular pH and migration of human polymorphonuclear leucocytes.

@article{Ritter1998EffectOI,
  title={Effect of inhibitors of Na+/H+-exchange and gastric H+/K+ ATPase on cell volume, intracellular pH and migration of human polymorphonuclear leucocytes.},
  author={Markus Ritter and Peter Schratzberger and Heidi Rossmann and Eichm{\"u}ller W{\"o}ll and Karl Seiler and Ursula Seidler and Norbert Reinisch and Christian Matthias K{\"a}hler and Heinz Zwierzina and Hans Jochen Lang and Florian Lang and Markus Paulmichl and Christian J Wiedermann},
  journal={British journal of pharmacology},
  year={1998},
  volume={124 4},
  pages={627-38}
}
1. Stimulation of chemotaxis of human polymorphonuclear leucocytes (PMNs) with the chemoattractive peptide fMLP (N-formyl-Met-Leu-Phe) is paralleled by profound morphological and metabolic alterations like changes of intracellular pH (pHi) and cell shape. The present study was performed to investigate the interrelation of cell volume (CV) regulatory ion transport, pHi and migration of fMLP stimulated PMNs. 2. Addition of fMLP to PMNs stimulated directed migration in Boyden chamber assays and… CONTINUE READING

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