Effect of inhibition of the ROCK isoform on RT2 malignant glioma cells.

@article{Inaba2010EffectOI,
  title={Effect of inhibition of the ROCK isoform on RT2 malignant glioma cells.},
  author={Nobuharu Inaba and Sho Ishizawa and Masaki Kimura and Kouki Fujioka and Michiko Watanabe and Toshiaki Shibasaki and Yoshinobu Manome},
  journal={Anticancer research},
  year={2010},
  volume={30 9},
  pages={3509-14}
}
BACKGROUND Malignant glioma is one of the most intractable diseases in the human body. Rho-kinase (ROCK) is overexpressed and has been proposed as the main cause for the refractoriness of the disease. Since efficacious treatment is required, this study investigated the effect of inhibition of ROCK isoforms. MATERIALS AND METHODS The short hairpin RNA transcription vector was transfected into the RT2 rat glioma cell line and the characteristics of the cells were investigated. The effect of… CONTINUE READING