Effect of inhibition of MAO and COMT on intrarenal dopamine and serotonin and on renal function.

@article{Wang2001EffectOI,
  title={Effect of inhibition of MAO and COMT on intrarenal dopamine and serotonin and on renal function.},
  author={Yanping Wang and Theresa J. Berndt and Jennifer M. Gross and Mary A. Peterson and Minna J So and Franklyn G. Knox},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2001},
  volume={280 1},
  pages={R248-54}
}
The purpose of the present investigation was to study the effects of inhibition of monoamine oxidase (MAO) and/or catechol-O-methyltransferase (COMT), enzymes involved in the degradation of dopamine (DA) and serotonin (5-HT), on intrarenal DA and 5-HT, as reflected in the renal interstitial fluid (RIF) microdialysate and urine, and on renal function. Inhibition of MAO selectively increased RIF 5-HT from 3.16 +/- 0.38 to 8.03 +/- 1.83 pg/min (n = 7, P < 0.05), concomitant with decreases in mean… CONTINUE READING

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