Effect of inhibiting the signal of mammalian target of rapamycin on memory T cells.

@article{Chen2014EffectOI,
  title={Effect of inhibiting the signal of mammalian target of rapamycin on memory T cells.},
  author={Shuo Chen and Dengfeng Liu and J Wu and Bi Yun Xu and Kai Lu and Weidong Zhu and Ming Chen},
  journal={Transplantation proceedings},
  year={2014},
  volume={46 5},
  pages={1642-8}
}
BACKGROUND Mammalian target of rapamycin (mTOR) signaling is crucial to the activation and proliferation of T cells. Memory T cells can significantly hinder the induction of transplant tolerance. Resent research demonstrates that mTOR signaling regulates the survival and function of memory T cells. MATERIALS AND METHODS Naïve T cells were adoptively transferred to Rag(-/-) mice to generate similar memory T cells that undergo homeostatic proliferation. These memory T cells were then used to… CONTINUE READING