Effect of inhaled prostaglandin E2 on allergen-induced asthma.

  title={Effect of inhaled prostaglandin E2 on allergen-induced asthma.},
  author={Ian D. Pavord and Clint S Wong and Jonathan Williams and Anne E Tattersfield},
  journal={The American review of respiratory disease},
  volume={148 1},
Prostaglandin E2 (PGE2) is produced in the lung but unlike most other lipid mediators has potentially important antiallergic effects. Whether these properties are relevant to asthma has not been established. The effect of inhaled PGE2 on allergen-induced asthma was examined in a double-blind crossover study of eight subjects with asthma. In Study 1 subjects inhaled 100 micrograms PGE2 or placebo 5 min before a normal saline challenge, and FEV1 and bronchial reactivity to methacholine was… CONTINUE READING

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